Glutathione S-transferase Activity in Diagnostic Pathology
نویسندگان
چکیده
منابع مشابه
Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer.
The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of using the glutathione S-transferase (GST) activity of blood lymphocytes and GST-mu expression as biomarkers of risk for colorectal cancer. GST acti...
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AIM Helicobacter pylori infection, though common, leads to gastric cancer (GC) in less than 1% individuals, suggesting the role of host factors. We previously reported the role of glutathione-S-transferase (GST) polymorphisms, the gene encoding a carcinogen-detoxifying enzyme, in GC. This study was aimed to evaluate GST enzyme activity, GST polymorphism, glutathione (GSH) levels and H. pylori i...
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Several synthetic pesticides and allelochemicals used to treat Triatoma infestans adults by topic application showed some degree of cytosolic glutathione S-transferase (GST) induction. General inducers of detoxication systems such as phenobarbital and 3-methylcholantrene topically applied on T. infestans resulted in no GST induction. Meanwhile, general insecticide synergist such as piperonyl bu...
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The role of glutathione S transferase (GST) in the detoxification mechanisms in different organs is discussed in recent papers. In rat brain, where GST is located in the astrocytes/1-3/, the information concerning this topic is scarce. We present information about the levels of GST specific activity (GST-SA) in different rat brain areas and the effect of placental tissue homogenate (PTH), which...
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Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) P1-1, an enzyme which displays antiapoptotic activity and is also involved in the cellular resistance to anticancer drugs. These new inhibitors are not tripeptide glutathione-peptidomimetic molecules and display lipophylic properties suitable for crossing the p...
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ژورنال
عنوان ژورنال: Journal of Postgenomics Drug & Biomarker Development
سال: 2015
ISSN: 2153-0769
DOI: 10.4172/2153-0769.1000153